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Xanax Online Abstract - May 16, 2005
Anxiolytic suppression of repetitive transcranial magnetic stimulation-induced anxiety in the rats.
Isogawa K, Fujiki M, Akiyoshi J, Tsutsumi T, Kodama K, Matsushita H, Tanaka Y, Kobayashi H.
Department of Neuropsychiatry, Oita University Faculty of Medicine, Oita 879-5593, Japan.
Repetitive transcranial magnetic stimulation (rTMS) is effective
for treatment of several psychiatric disorders such as depression
and anxiety disorder. However, some reports suggest that rTMS
induced anxiety in normal volunteers. Consistent with this observation,
we have reported that chronic rTMS induces anxiety in normal rats
which was suppressed by chronic treatment, but not acute paroxetine
treatment. The current study evaluates rTMS as animal model of
anxiety by investigating the effect of rTMS on anxiety behaviors
and the ability of standard anxiolytics to block expression of
these behaviors. We found that 10-day rTMS induced anxiety in
normal rats, as evidenced by expression of anxiety behaviors in
the elevated plus-maze. This anxiety was suppressed by acute treatment
with diazepam, alprazolam, or buspirone suggesting that chronic
rTMS treatment provides a good animal model for anxiety.
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